Identify the option that has the most appropriate sequence such that a coherent paragraph is formed:

P. Over time, such adaptations lead to significant evolutionary changes with the potential to shape the development of new species.

Q. In natural world, organisms constantly adapt to their environments in response to challenges and opportunities.

R. This process of adaptation is driven by the principle of natural selection, where favourable traits increase an organism's chances of survival and reproduction.

S. As environments change, organisms that can adapt their behaviour, structure and physiology to such changes are more likely to survive.